Journal: Nature Communications

Article Title: Long-term brain pressure monitoring via a discrete microimplant; a first-in-human safety and initial efficacy trial in adults and children with hydrocephalus

doi: 10.1038/s41467-026-70864-8

Figure Lengend Snippet: A Immunohistochemistry of sheep brain tissue of the round shunt tubing adjacent to the sensor at 6 months post implantation (scale bar 2.5 mm) (6 sheep had histology performed). Green staining shows neurons stained with NeuN and indicates no widespread neuronal loss. Yellow shows quiescent microglia (IBA-1), indicating stabilisation of the tissue response at 6 months post-implantation. Pink shows astrocytes (GFAP) indicating minimal glial encapsulation. B Schematic showing the placement of the sensor directly within the parenchyma via a separate burr hole from the shunt. C Post-operative MRI image illustrating an approximate 22 mm artifact associated with the sensor. D Post-operative CT image showing the sensor adjacent to a shunt catheter within the cortex.

Article Snippet: Rabbit polyclonal, primary antibodies used were: glial fibrillary acidic protein (GFAP), 1:1000 (Dako, Z0334), ionized calcium-binding adapter protein (IBA-1), 1:500 (Wako 019-19741), and collagen IV (Col4A), 1:300 (Biorbyt 340147).

Techniques: Immunohistochemistry, Staining, Encapsulation

Journal: Materials Today Bio

Article Title: Dual-responsive PDA-HP hydrogel enables mitochondria-targeted mild photothermal therapy for spinal cord repair

doi: 10.1016/j.mtbio.2026.102783

Figure Lengend Snippet: PDA-HP/NIR treatment suppresses glial activation and promotes a shift toward anti-inflammatory polarization following SCI. (A) Representative fluorescence images and quantification showing GFAP (green) and IBA1 (red) staining of spinal cord sections in each group. Scale bars are 10 μm. Quantification of mean fluorescence intensity is shown in (B, C). Data are presented as mean ± SD ( n = 6, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001). (D) Representative fluorescence images and quantification showing Arg-1 (green) and iNOS (red) staining of spinal cord sections in each group. Scale bars are 10 μm. Quantification of mean fluorescence intensity is shown in (E, F). Data are presented as mean ± SD ( n = 6, ∗ p = 0.011, ∗∗∗ p < 0.001, and ∗∗∗∗ p < 0.0001). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

Article Snippet: Samples were then incubated overnight at 4 °C with the following primary antibodies: GFAP (astrocyte marker, 1:500, Proteintech, China), Iba1 (microglia marker, 1:500, Proteintech, China), Arg-1 (M2 phenotype marker, 1:500, Proteintech, China), iNOS (M1 phenotype marker, 1:500, Proteintech, China).

Techniques: Activation Assay, Fluorescence, Staining